The neuroprotective effects of theanine in different doses and protocols of administration in the rat model of focal cerebral ischemia
https://doi.org/10.24884/1682-6655-2012-11-1-82-85
Abstract
This study was aimed to evaluate neuroprotective effect of gamma-glutamylethylamide (L-theanine) in brain ischemic damage in rats, caused by left middle cerebral artery occlusion. Theanine was administered intraperitoneally 1mg/kg and 4 mg/kg 30 minutes before ischemia and 3, 12, 24 hours after left middle cerebral artery occlusion. The necrosis size in rats that received theanine 30 minutes before ischemia and 3 and 12 hours after the beginning of reperfusion was significantly decreased 2 days after ischemia. Furthermore, the assessment of animal status on the second day after left middle cerebral artery occlusion revealed significant neurological deficiency reduction in the same experimental groups. Theanine, administered 24 hours after the beginning of reperfusion, failed to change necrosis size and neurological deficiency extent significantly. Thereby, it has been proved, that theanine, injected before brain ischemia and 3 and 12 hours after it, provides brain protection, that potentially might be used in prophylactic and therapy of brain vascular diseases.
About the Authors
A. S. Dayneko
Saint-Petersburg Pavlov State Medical University
Russian Federation
Russian Federation
A. V. Simanenkova
Saint-Petersburg Pavlov State Medical University
Russian Federation
Russian Federation
M. S. Prosvirnina
Saint-Petersburg Pavlov State Medical University
Russian Federation
Russian Federation
M. A. Zuhurova
Saint-Petersburg Pavlov State Medical University
Russian Federation
Russian Federation
T. D. Vlasov
Saint-Petersburg Pavlov State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Dayneko A.S., Simanenkova A.V., Prosvirnina M.S., Zuhurova M.A., Vlasov T.D. The neuroprotective effects of theanine in different doses and protocols of administration in the rat model of focal cerebral ischemia. Regional blood circulation and microcirculation. 2012;11(1):82-85. (In Russ.) https://doi.org/10.24884/1682-6655-2012-11-1-82-85
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