Restorative effect of hormones on the neurogenic vasoreactivity
https://doi.org/10.24884/1682-6655-2011-10-4-65-72
Abstract
The effects of noradrenaline and melatonin on the isometric contraction of the juvenile rat tail artery segment to electrical field stimulation of perivascular nerves were studied and compared. Both hormones in concentration of 0.1 uM were shown to potentiate similarly the contractile response decreased in the course of experiments and this potentiation was proportional to the extent of the preceding decrease in the response. The noradrenaline- and melatonin-evoked potentiation was much more pronounced after the substantial decrease in the neurogenic contraction under acidic conditions and was not changed by the NO synthase inhibition. The results suggest the existence of the mechanism by which different hormones in specific concentration can maintain the neurogenic signal efficiency to constrict the blood vessels.
About the Authors
V. N. Yartsev
Laboratory of Circulation Physiology, Pavlov Institute of Physiology, Saint-Petersburg
Russian Federation
Russian Federation
O. V. Karachentseva
Laboratory of Circulation Physiology, Pavlov Institute of Physiology, Saint-Petersburg
Russian Federation
Russian Federation
D. P. Dvoretsky
Laboratory of Circulation Physiology, Pavlov Institute of Physiology, Saint-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Yartsev V.N., Karachentseva O.V., Dvoretsky D.P. Restorative effect of hormones on the neurogenic vasoreactivity. Regional blood circulation and microcirculation. 2011;10(4):65-72. (In Russ.) https://doi.org/10.24884/1682-6655-2011-10-4-65-72
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