The role of connexin structures (gap-junction and hemichannels) in the pathogenesis of ischemic brain damage: status update on the problem
https://doi.org/10.24884/1682-6655-2016-15-3-4-14
Abstract
This review is devoted to a discussion of the dual role of connexin intercellular structures and gap junction (GJ) in normal and cerebral ischemia. The review describes the structure and form of connexin structures such as gap junctions and hemichannels. It is shown that the properties of connexin structures depend on the connexins. We describe a substance that can be transported through connexin structure. The data on the possible increase in the number of GJ after ischemia/cerebral hypoxia. A hypothesis about the development of post-ischemic neuronal syncytium formation by GJ. We discuss ways of blocking of GJ to reduce post-ischemic brain damage.
About the Authors
E. V. Melnikova
Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
A. A. Shmonin
Pavlov First Saint-Petersburg State Medical University; Federal Almazov North-West Medical Research Centre
Russian Federation
Russian Federation
N. M. Paramonov
Pavlov Institute of Physiology Russian Academy of Sciences
Russian Federation
Russian Federation
K. A. Mishchenko
Outpatient department «Consult and Diagnostic Center and Outpatient department»
Russian Federation
Russian Federation
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Review
For citations:
Melnikova E.V., Shmonin A.A., Paramonov N.M., Mishchenko K.A. The role of connexin structures (gap-junction and hemichannels) in the pathogenesis of ischemic brain damage: status update on the problem. Regional blood circulation and microcirculation. 2016;15(3):4-14. (In Russ.) https://doi.org/10.24884/1682-6655-2016-15-3-4-14
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