Hemostatic potential providing with microparticles in patients with atherosclerosis of the vessels of the lower extremities
https://doi.org/10.24884/1682-6655-2013-12-4-75-80
Abstract
This study included 29 patients with atherosclerosis of the vessels of the lower extremities. In the current research the hypercoagulation syndrome that occurs in such patients was investigated. The purpose of the study was to estimate enhance of prothrombogenic potential caused by microparticles. The common blood coagulation tests and thrombin generation caused by microparticles had been analyzed. It has found that the common used blood tests are not always sufficient for detection of hypercoagulation in patients with atherosclerosis of the vessels of the lower extremities. Microparticles enhance thrombin generation and increase prothrombogenic potential of these patients due to tissue factor expressed on their surfaces. Microparticles of patients with atherosclerosis of the vessels of the lower extremities have anticoagulant activity which may limit thrombin generation.
About the Authors
O. Yu. Matvienko
Russian Research Institute of Hematology and Transfusiology
Russian Federation
Russian Federation
Yu. A. Namestnikov
Russian Research Institute of Hematology and Transfusiology
Russian Federation
Russian Federation
O. G. Golovina
Russian Research Institute of Hematology and Transfusiology
Russian Federation
Russian Federation
N. B. Saltykova
Russian Research Institute of Hematology and Transfusiology
Russian Federation
Russian Federation
L. P. Papayan
Russian Research Institute of Hematology and Transfusiology
Russian Federation
Russian Federation
N. N. Petrischev
Russian Research Institute of Hematology and Transfusiology
Russian Federation
Russian Federation
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Review
For citations:
Matvienko O.Yu., Namestnikov Yu.A., Golovina O.G., Saltykova N.B., Papayan L.P., Petrischev N.N. Hemostatic potential providing with microparticles in patients with atherosclerosis of the vessels of the lower extremities. Regional blood circulation and microcirculation. 2013;12(4):75-80. (In Russ.) https://doi.org/10.24884/1682-6655-2013-12-4-75-80
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