Directions to correction of microvascular radicular disorders at intervertebral disc herniations

In case of disc herniated appearance it's often compression of radicular nerve happens, which accompanies with different clinical manifestation and microvascular disorders. In clinical practice of specialists dealing with sciatica it's common to use medications that take effect on microvascular regulation. Investigation of of pathophysiologic aspects of this effect is actual aim of number specialists facing with that question. Pupose - intraoperative evaluation of directions to pharmacologic correction of intraradicular microcirculation before and after surgical discectomy in sciatica patients. In this study were included 87 adult people with clinical manifestation of radiculopathy. During the standart Caspar's surgical discectomy the microvasular oscillations were measured from the radicular nerve using laser Doppler flowmetry method (LDF). All the patients were divided in 2 groups: I - control group - (56 adults - 22 females and 36 males) in which measures were taken before and after discectomy, without medications injection. II group (31 adults - 19 females and 12 males) - in which oscillations were measured before decompression, after intravenous injection of one medication: IIE (14 patients) - euphyllin, IID (11 patients) - dexamethasone and IIR (6 patients) - 30000 ME dextrane (rheopolyglucine), and after discectomy. Quantitative evaluation was assessed with microcirculation rate (MR, in perfusion units, p.u.) and qualitative evaluation with means of standardized amplitude of neurogenic sympathetic (An, 0.02-0.046Hz), myogenic (Am, 0.07-0.15Hz), respiratory venous (Ar, 0.15-0.4Hz) and cardial (Ac, 0.8-1.6Hz) rhythms. All the investigated medications showed their intraoperative influence on microcirculation. The most effective medication increasing MR and perfusion pressure was the group of middle molecular dextrane - rheopolyglucin.

спинно-мозговой корешок, радикулопатия, микроваскуляризация, лазерная допплеровская флоуметрия, дексаметазон, эуфиллин, реополиглюкин, декстран, nerve root, microvascularization, laser dopplerflowmetry, dexamethasone, euphillin, rheopolyglucin, radicular blood flow, sciatica, radiculopathy

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