Predictors and blood markers of abdominal aortic calcification
https://doi.org/10.24884/1682-6655-2012-11-4-12-17
Abstract
Some authors are reported that abdominal aortic calcification is a strong predictor of systematic atherosclerosis and significantly impacts to the atherosclerotic burden. This review summarizes the present knowledge regarding risk factors and markers of abdominal aortic calcification. Well established risk factors for abdominal aortic calcification included smoking, arterial hypertension and diabetes mellitus. The role of blood markers (such as lipids, osteoprotegerin, osteopontin, C-reactive protein, homocysteine, fetuin-A) as risk factors for abdominal aortic calcification is debated. Further studies are required to critically assess the role of outlines blood markers.
About the Authors
M. V. Melnikov
North-Western state medical university named after I. I. Mechnikov
Russian Federation
Russian Federation
V. A. Zelinskiy
North-Western state medical university named after I. I. Mechnikov
Russian Federation
Russian Federation
A. U. Apresyan
North-Western state medical university named after I. I. Mechnikov
Russian Federation
Russian Federation
References
1. Allender, S. European cardiovascular disease statistics / S. Allender [et al] // European Heart network. - 2008. - P. 112.
2. Allison, M. A. Ethnic-specific risks for atherosclerotic calcification of the thoracic and abdominal aorta (from the Multi-Ethnic Study of Atherosclerosis) / M. A. Allison [et al] // Am. J. Cardiol. - 2009. - № 104 (6). - Р. 812-817.
3. Allison, M. A. Patterns and risk factor for systematic calcified atherosclerosis / M. A. Allison, M. H. Criqui, C. M. Wright // Arterioscler. Thromb. Vasc. Biol. - 2004. - № 24 (2). - Р. 331-336.
4. Allison, M. A. The differential associations between HDL, non-HDL and total cholesterols and atherosclerotic calcium deposits in multiple vascular beds / M. A. Allison, P. Pavlinac, C. M. Wright // Atheroscler. - 2007. - № 194 (2). - Р. 87-94.
5. Arai, Y. Long-term effects of lipid lowering therapy on atherosclerosis of abdominal aorta in patients with hypercholesterolemia: non-invasive evaluation by new image analysis program / Y. Arai [et al] // Angiol. - 2002. - № 53 (I). - Р. 58-68.
6. Auerbach, O. Atherosclerosis and aneurysm of aorta in relation to smoking habits and age / O. Auerbach, L. Garfinkel // Chest. - 1984. - № 78 (6). - Р. 805-809.
7. Barreto, D. V. Prognostic implication of plasma osteopontin levels in patients with chronic kidney disease / D. V. Barreto [et al] // Nephron. Clin. Pract. - 2010. - № 117 (4). - Р. C363-C372.
8. Bolland, M. J. Abdominal aortic calcification on vertebral morphometry images predicts incident myocardial infarction / M. J. Bolland [et al]// J. Bone Miner. Res. - 2010. - № 25 (3). - Р. 505-512.
9. Clancy, P. Assessment of a serum assay for quantification of abdominal aortic calcification / P. Clancy [et al] // Arterioscler. Thromb Vasc. Biol. - 2006. - № 26 (II). - Р. 2574-2576.
10. Cozzolino, M. Serum fetuin-A levels link inflammation and cardiovascular calcification in hemodialysis patients / M. Cozzolino [et al] // Am. J. Nephrol. - 2006. - № 26 (5). - Р 423-429.
11. Dixon, A. Age-related changes in the abdominal aorta shown by computed tomography / A. Dixon, J. Lawrence, J. Mitchell // Clin. Radiol. - 1984. - № 35 (1). - Р. 33-37.
12. Doherty, T. M. Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads / T. M. Doherty [et al] // Proc. Natl. Acad. Sci. - 2003. - № 100 (20). - Р. 11201-11206.
13. Faxon, D. P. Atherosclerotic vascular disease: executive summary: atherosclerotic vascular conference proceeding for healthcare professional from a special writing group of the American Heart Assotiation / D. P. Faxon [et al] // Circulation. - 2004. - № 109. - Р. 2595-2604.
14. Hak, A. E. Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study / A. E. Hak [et al] // Arterioscler. Thromb Vasc. Biol. - 2000. - № 20 (8). - Р. 1926-1931.
15. Hanada, S. Assessment and significance of abdominal aortic calcification in chronic kidney disease / S. Hanada [et al] // Nephrol. Dial. Transplant. - 2010. - № 25 (6). - Р 1888-1895.
16. Hirose, N. Association of mild hyperhomocysteinemia with aortic calcification in hypercholesterolemic patients / N. Hirose [et al] // J. Atheroscler. Thromb. - 2001. - № 8 (3). - Р. 91-94.
17. Jamal, S. A. Hyperhomocysteinaemia and aortic calcification are associated with fractures in patients on haemodialysis / S. A. Jamal, R. E. Leiter, D. C. Bauer // QJM. - 2005. - № 98 (8). - Р. 575-579.
18. Jayalath, R. W. Aortic Calcification / R. W. Jayalath, S. H. Mangan, J. Golledge // Eur. J. Vasc. Endovasc. Surg. - 2006. - № 30 (5). - Р. 476-488.
19. Jensky, N. E. Blood pressure and vascular calcification / N. E. Jensky [et al] // Hypertension. - 2010. - № 55 (4). - Р. 990-997.
20. Kawaguchi, Y. Is atherosclerosis accelerated by CAPD? / Y. Kawaguchi [et al] // Perit. Dial. Int. - 1996. - № 16 (1). - Р. S223-S230.
21. Kiel, D. P. Bone loss and the progression of abdominal aortic calcification over 25-year period: The Framingham Heart Study / D. P. Kiel [et al] // Calcif. Tissue Int. - 2001. - № 68 (5). - Р. 271-276.
22. Kimura, K. Factors associated with calcification of the abdominal aorta in hemodialysis patients / K. Kimura [et al] // Kidney Int. - 1999. - № 71. - Р. S238-S241.
23. Kuller, L. H. Coronary and aortic calcification among women 8 years after menopause and their premenopausal risk factors: the healthy women study / L. H. Kuller [et al] // Arterioscler. Thromb Vasc. Biol. - 1999. - № 19 (9). - Р. 2189-2198.
24. Lehto, S. Medial artery calcification: a neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitus / S. Lehto [et al] // Arterioscler. Thromb. Vasc. Biol. - 1996. - № 16. - Р. 978-983.
25. Li, J. Aortic calcification on plain chest radiography increases risk for coronary artery disease / J. Li [et al]// Chest. - 2002. - № 121. - Р. 1468-1471.
26. Matsushita, M. Relationship between aortic calcification and atherosclerotic disease in patients with abdominal aortic aneurysm / M. Matsushita [et al] // Int. Angiol. - 2000. - № 19 (3). - Р. 276-279.
27. Miwa, Y. Pulse pressure is an independent predictor for the progression of aortic wall calcification in patient with controlled hyperlipidemia / Y. Miwa [et al] // Hypertension. - 2004. - № 43. - Р. 536-540.
28. Niskanen, L. K. Aortic and lower limb artery calcification in type 2 (non-insulin-dependent) diabetic patients and non-diabetic control subjects. A five-year follow-up study / L. K. Niskanen [et al] // Atheroscler. - 1990. - № 84 (1). - Р. 61-71.
29. Nitta, K. The progression of vascular calcification and serum osteoprotegerin levels in patients on long-term haemodialysis / K. Nitta [et al] // Am. J. Kidney Dis. - 2003. - № 42 (2). - Р. 303-309.
30. Nitta, K. Soluble osteopontin and vascular calcification in hemodialysis patients / K. Nitta [et al] // Nephron. - 2001. - № 89 (4). - Р. 455-458.
31. O'Donnel, C. J. Evidence for heritability of abdominal aortic calcific deposits in The Framingham Heart Study / C. J. O'Donnel // Circulation. - 2002. - № 106. - Р. 337-341.
32. Reaven, P. D. Reduced coronary artery and abdominal aortic calcification in Hispanics with type 2 diabetes / R. D. Reaven, J. Sacks // Diabetes Care 2004. - № 27 (5). - Р. 1115-1120.
33. Rodondi, N. Association between aortic calcification and total and cardiovascular mortality in older women / N. Rodondi [et al] // J. Intern. Med. - 2007. - № 261 (3). - Р. 238-244.
34. Schoppet, M. RANKL ligand and osteoprotegerin: paracrine regulators of bone metabolism and vascular function / M. Schoppet, K. T. Preissner. L. S. Hofbauer // Arterioscler. Thromb Vasc. Biol. - 2002. - № 22. - Р. 549-553.
35. Shiota, J. Relationship between coronary and abdominal calcification score, serum osteoprotegerin (OPG), and serum tartrate-resistant acid phosphatase (TRACP)-5b in pre-dialysis CKD patients / J. Shiota [et al] // Nippo Jinzo Gakkai Shi. - 2010. - № 52 (8). - Р. 1022-1028.
36. Takasu, J. Aortic atherosclerosis detected with electron beam CT as a predictor of obstructive coronary artery disease / J. Takasu, S. Mao, M. J. Budoff // Acad Radiol. - 2003. - № 10 (6). - P. 631-637.
37. Temmar, M. Pulse wave velocity and vascular calcification at different stage of chronic kidney disease / M. Temmar [et al] // Hypertens. - 2010. - № 28 (1). - P. 163-169.
38. Tintut, Y. Recent advances in multifactorial regulation of vascular calcification / Y. Tintut, L. L. Demer // Curr. Opin. Lipidol. - 2001. - № 12 (5). - P. 555-560.
39. Troxclair, D. Arterial calcification as a marker for atherosclerosis in three Arctic populations / D. Troxclair [et al] // Int. J. Circumpolar. Health. - 1998. - № 57. - Suppl. 1. - P. 306-311.
40. Van Campenhout, A. Role of homocysteine in aortic calcification and osteogenic cell differentiation / A. Van Campenhout[et al] // Atheroscler. - 2009. - № 202 (2). - P 557-566.
41. Van der Meer, I. M. C-reactive protein predicts progression of atherosclerosis measured at various sites in the arterial tree: the Rotterdam study / I. M. Van der Meer [et al] // Stroke. - 2002. - № 33 (12). - P. 2750-2755.
42. Wang, M. Vascular calcification in maintenance hemodialysis patients / M. Wang [et al] // Blood Purif - 2009. - № 28 (1). - P. 15-20.
43. Wilson, P. W. F. Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality / P. W. F. Wilson // Circulation. - 2001. - № 103 (11). - P. 1529-1534.
44. Witteman, J. C. Cigarette smoking and development and progression of aortic atherosclerosis: a 9-year population based follow-up study in women / J. C. Witteman [et al] // Circulation. - 1993. - № 88 (5). - P. 2156-2162.
45. Wong, N. D. Abdominal aortic calcium and multi-site atherosclerosis: The Multiethnic Study of Atherosclerosis / N. G. Wong [et al] // Atheroscler. - 2011. - № 214 (2). - P 436-441.
Review
For citations:
Melnikov M.V., Zelinskiy V.A., Apresyan A.U. Predictors and blood markers of abdominal aortic calcification. Regional blood circulation and microcirculation. 2012;11(4):12-17. (In Russ.) https://doi.org/10.24884/1682-6655-2012-11-4-12-17
Views:
432
Email this article 
