Inhibition of COX reduces the size of necrosis and death of neurons in the cerebral cortex of rats with ischemic insult and insult complicated with reperfusion of carotid arteries
https://doi.org/10.24884/1682-6655-2012-11-4-83-90
Abstract
The work addresses neuroprotectoral action of Lornoxicam, a non-steroidal anti-inflammatory drug, on rats with modeled ischemic insult (OMCA) and ischemic insult complicated with reperfusion injury (OMCA+RI). In the first case we irreversibly coagulated the medial cerebral artery and the frontal vein; in the latter case two carotid arteries were clamped in addition to OMCA and reperfused in one hour. Lornoxicam was injected intravenously 20 minutes after the beginning of ischemia and intra-abdominally 24 and 72 hours later. A dosage of 230 mkg/kg recommended for humans was used. Possible protective action of the drug was studied 28 days after OMCA in each experimental group of N=3 species. We have observed three main morphological effects of Lornoxicam: 1) Lornoxicam induced 25-40 % reduction of cerebral cortex necrosis size both for rats with OMCA and with OMCA+RI; 2) neuroglial index was significantly reduced in 28 days after the surgery due to increase in number of survived neurons in the penumbra area; 3) the volume of neuron nuclei significantly increased for animals with insult.
Keywords
мозг,
ишемия,
реперфузия,
нейропротекция,
"Лорноксикам",
brain,
ischemia,
reperfusion,
neuroprotection,
lornoxicam
About the Authors
M. V. Tikhonovich
M. V. Lomonosov Moscow State University
Russian Federation
Russian Federation
S. A. Gavrilova
M. V. Lomonosov Moscow State University
Russian Federation
Russian Federation
I. V. Taratin
M. V. Lomonosov Moscow State University
Russian Federation
Russian Federation
I. V. Leonenko
M. V. Lomonosov Moscow State University; The Russian National Research Medical University named after N. I. Pirogov
Russian Federation
Russian Federation
E. I. Parnes
Central Hospital of Civil Aviation
Russian Federation
Russian Federation
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Review
For citations:
Tikhonovich M.V., Gavrilova S.A., Taratin I.V., Leonenko I.V., Parnes E.I. Inhibition of COX reduces the size of necrosis and death of neurons in the cerebral cortex of rats with ischemic insult and insult complicated with reperfusion of carotid arteries. Regional blood circulation and microcirculation. 2012;11(4):83-90. (In Russ.) https://doi.org/10.24884/1682-6655-2012-11-4-83-90
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