Peculiarities of morpho-functional characteristics of platelets in women with early and late preeclampsia
https://doi.org/10.24884/1682-6655-2024-23-2-52-59
Abstract
Introduction. In preeclampsia (PE), the hemostasis system, including the platelet component, changes significantly. The purpose of the work was to identify the peculiarities of the morpho-functional characteristics of platelets in women with early and late PE. Material and methods. The main group consisted of 26 women with early PE and 46 women with late PE. The control group consisted of women with normal pregnancies without hypertensive disorders, of whom 17 were at a gestational age of 260–336 weeks and 42 were at a gestational age of 340–394 weeks. The ADVIA 2120i hematology analyzer was used to evaluate platelet concentration (PLT), platelet distribution width (PDW), mean platelet volume (MPV), concentration of large platelets (Large PLT), percentage of large platelets from the total number of platelets (%LP), mean platelet component concentration (MPC), mean dry platelet mass (MPM). Results. Women with early PE have increased PDW, MPV, LargePlt, %LP and MPM indices compared to women with normal pregnancies up to 34 weeks. Female patients with late PE had lower PLT and higher PDW, %LP, MPC, MPM compared to women with normal pregnancies after 34 weeks. In late PE, PLT is reduced and PDW, %LP and MPM are increased compared to early PE. Conclusion. The detected changes in platelet indices in women with PE, regardless of the period of its onset, indirectly indicate increased thrombopoiesis and high functional activity of young platelets. However, the mechanisms that increase platelet activation in early and late preeclampsia differ.
About the Authors
M. M. Klycheva
Gorodkov Ivanovo Research Institute of Maternity and Childhood
Russian Federation
Russian Federation
Klycheva Maya M. – Candidate (PhD) of Biological Sciences, Researcher, Laboratory of Clinical Biochemistry and Genetics
20, Pobedy str., Ivanovo, 153045
I. A. Panova
Gorodkov Ivanovo Research Institute of Maternity and Childhood
Russian Federation
Russian Federation
Panova Irina A. – MD, Prof., Head, Department of Obstetrics and Gynecology
20, Pobedy str., Ivanovo, 153045
S. B. Nazarov
Gorodkov Ivanovo Research Institute of Maternity and Childhood
Russian Federation
Russian Federation
Nazarov Sergei B. – MD, Prof., Deputy Director for Research
20, Pobedy str., Ivanovo, 153045
G. N. Kuzmenko
Gorodkov Ivanovo Research Institute of Maternity and Childhood
Russian Federation
Russian Federation
Kuzmenko Galina N. – MD, Leading Researcher, Laboratory of Clinical Biochemistry and Genetics
20, Pobedy str., Ivanovo, 153045
R. I. Sadov
Gorodkov Ivanovo Research Institute of Maternity and Childhood
Russian Federation
Russian Federation
Sadov Ruslan I. – Candidate (PhD) of Medical Sciences,
Doctor, Admission Department, Gynecological Clinic
20, Pobedy str., Ivanovo, 153045
I. G. Popova
Gorodkov Ivanovo Research Institute of Maternity and Childhood
Russian Federation
Russian Federation
Popova Irina G. – PhD in Medical sciences, research officer laboratory of clinical biochemistry and
genetics
20, Pobedy str., Ivanovo, 153045
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For citations:
Klycheva M.M., Panova I.A., Nazarov S.B., Kuzmenko G.N., Sadov R.I., Popova I.G. Peculiarities of morpho-functional characteristics of platelets in women with early and late preeclampsia. Regional blood circulation and microcirculation. 2024;23(2):52-59. (In Russ.) https://doi.org/10.24884/1682-6655-2024-23-2-52-59
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