The investigation of cardioprotective effects of novel necroptosis inhibitors - necrosulfonamide and necrostatin-1s in the rat model of isolated perfused rat heart
https://doi.org/10.24884/1682-6655-2016-15-3-81-85
Abstract
Minimization of irreversible myocardial damage after ischemia-reperfusion episode remains valid and unsolved problem. Among of many pharmacological agents have been effective in experimental studies, only a few of them are evidence of its efficacy in clinical trials. This is largely explained by the mechanism of action of these compounds, aimed primarily at preventing reperfusion injury, and do not affect myocardial cells subjected to prolonged ischemia without reperfusion. In recent years, the interest of researchers confined to the mechanisms of programmed necrosis or necroptosis, which morphologically has no different to necrosis, but has molecular targets for suppression. In this paper, on the model of global ischemia-reperfusion in rats we have studied cardioprotective effects of high-activity and low-toxicity necroptosis inhibitors - necrosulfonamide and necrostatin-1s. We demonstrated the infarct-limiting effect of these compounds, as well as the best parameters of intracardiac hemodynamics after an episode of global ischemia-reperfusion. We believe these compounds are interesting for further preclinical studies.
About the Authors
Yu. V. Dmitriev
Federal Almazov North-West Medical Research Centre
Russian Federation
Russian Federation
S. M. Minasian
Federal Almazov North-West Medical Research Centre; First I.P. Pavlov Federal Medical University
Russian Federation
Russian Federation
E. A. Demchenko
Federal Almazov North-West Medical Research Centre
Russian Federation
Russian Federation
V. K. Bayrasheva
Federal Almazov North-West Medical Research Centre; First I.P. Pavlov Federal Medical University
Russian Federation
Russian Federation
M. M. Galagudza
Federal Almazov North-West Medical Research Centre; First I.P. Pavlov Federal Medical University
Russian Federation
Russian Federation
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Review
For citations:
Dmitriev Yu.V., Minasian S.M., Demchenko E.A., Bayrasheva V.K., Galagudza M.M. The investigation of cardioprotective effects of novel necroptosis inhibitors - necrosulfonamide and necrostatin-1s in the rat model of isolated perfused rat heart. Regional blood circulation and microcirculation. 2016;15(3):81-85. (In Russ.) https://doi.org/10.24884/1682-6655-2016-15-3-81-85
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